Article
In vitro effect of the presence of human albumin or human serum on the bactericidal activity of daptomycin against strains with the main resistance phenotypes in Gram-positives.
The Journal of antimicrobial chemotherapy - 1 Jun 2007
Cafini F, Aguilar L, González N, Giménez M J, Torrico M, Alou L, Sevillano D, Vallejo P, Prieto J
Abstract excerpt
OBJECTIVES: Bactericidal activity depends on antibiotic-bacteria couples, resistance phenotype and theoretically on protein binding. This work explores the influence of protein binding on the bactericidal activity of two antibiotics, daptomycin versus vancomycin, that exhibit, respectively, different C(max) (56 versus 25.5 mg/L), protein binding (91.7% versus 36.9%) and thus theoretical free-drug fractions (4.7...
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