Article
Lack of association between the apolipoprotein E gene and aneurysmal subarachnoid hemorrhage in an Italian population.
Journal of neurosurgery - 1 Feb 2007
Fontanella Marco, Rainero Innocenzo, Gallone Salvatore, Rubino Elisa, Rivoiro Chiara, Valfrè Walter, Garbossa Diego, Nurisso Chiara, Ducati Alessandro, Pinessi Lorenzo
Abstract excerpt
OBJECT: The results of genome-wide scan studies have suggested the presence of a genetic risk factor for aneurysmal subarachnoid hemorrhage (SAH) on chromosome 19 (at 19p13). The apolipoprotein E (APOE) gene is located in this chromosomal region and encodes a protein that exerts several neuroprotective and neurotrophic functions in the brain. The purpose of this study was to evaluate whether a particular allele...
Topics
- Adult
- Aged
- Apolipoproteins E
- Case-Control Studies
- Cohort Studies
- Female
- Gene Frequency
- Genotype
- Glasgow Outcome Scale
- Humans
- Italy
- Male
- Middle Aged
- Subarachnoid Hemorrhage