Article
Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo study of the PB1 domain of Ref(2)P.
Genetics - 1 May 2007
Carré-Mlouka A, Gaumer S, Gay P, Petitjean A M, Coulondre C, Dru P, Bras F, Dezélée S, Contamine D
Abstract excerpt
Ref(2)P has been described as one of the Drosophila proteins that interacts with the sigma virus cycle. We generated alleles to identify critical residues involved in the restrictive (inhibiting viral multiplication) or permissive (allowing viral multiplication) character of Ref(2)P. We demonstrate that permissive alleles increase the ability of the sigma virus to infect Drosophila when compared to null alleles...
Topics
- Alleles
- Animals
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Evolution, Molecular
- Genes, Insect
- Genotype
- Mutation
- Nuclear Proteins
- Polymorphism, Genetic
- Protein Structure, Tertiary
- Rhabdoviridae