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Article

Cloning, expression, and promoter analysis of hepatic lipase derived from human hyperplastic adrenals: evidence for alternative mRNA splicing.

Cell biochemistry and biophysics - 1 Jan 2007

Botma Gert-Jan, Heuveling Mirjam, Lamers Jos M J, Jansen Hans, Verhoeven Adrie J M

Abstract excerpt

Human adrenals contain hepatic lipase (HL) activity, which is thought to facilitate the uptake of plasma cholesterol used in steroidogenesis. We show here that full-length HL mRNA is expressed in hyperplastic adrenals of patients with Cushing's disease. In addition, a splice variant that lacks exon-3 was detected in the human adrenals and hepatoma (HepG2) cells, but not in liver. In CAT-reporter assays using...

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Source

Identifiers

PMID: 17406067
DOI: 10.1385/cbb:47:1:149

Genes

CAT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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