Maternal origin of deletion 15q11-13 in 25/25 cases of Angelman syndrome.

doi:10.1007/BF00215668

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Article

Maternal origin of deletion 15q11-13 in 25/25 cases of Angelman syndrome.

Human genetics - 1 Feb 1992

Smith J C, Webb T, Pembrey M E, Nichols M, Malcolm S

Abstract excerpt

About half of the cases of Angelman syndrome arise from deletions of chromosome band 15q12. In 25 cases we have been able to determine the parental origin of the deletion and, in line with other reported cases, we have found the deletion to be of maternal origin. There were no exceptions. The par...

Topics

Abnormalities, Multiple
Alleles
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 15
Female
Genetic Markers
Humans
Male
Pedigree
Polymorphism, Genetic
Syndrome

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