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Article

Recurrence of a Phe31Ser mutation in the Gla domain of blood coagulation factor X, in unrelated Algerian families: a founder effect?

European journal of haematology - 1 May 2007

Akhavan Sepideh, Chafa Ouerdia, Obame Fatou Nsoure, Torchet Marie-Françoise, Reghis Abderrezak, Fischer Anne-Marie, Tapon-Bretaudière Jacqueline

Abstract excerpt

The presence of gene lesions in blood coagulation factor X (FX) was investigated in eight FX-deficient patients with severe bleeding symptoms, originating from five unrelated Algerian families (FX coagulant activity <1%, FX antigen ranging from 2% to 16%). A missense mutation (p.Phe31Ser) in the Gla domain was found in homozygous form for all patients but one, who is a compound heterozygote for the Phe31Ser...

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PMID: 17391309
DOI: 10.1111/j.1600-0609.2007.00836.x

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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