Article
BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers.
Oncogene - 6 Sept 2007
Yuli C, Shao N, Rao R, Aysola P, Reddy V, Oprea-llies G, Lee L, Okoli J, Partridge E, Reddy E S P, Rao V N
Abstract excerpt
Breast cancer gene 1 (BRCA1) mutations predispose women to breast and ovarian cancers and men to increased risks for prostate cancer. We have previously showed BRCA1 splice variant BRCA1a/p110 to induce apoptosis of human breast cancer cells. In the current study, stable expression of BRCA1a/p110 resulted in inhibition of growth of estrogen receptor (ER)-positive and triple-negative (TN) human breast, ovarian,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.