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Article

Matrix bound SFD mutant TIMP-3 is more stable than wild type TIMP-3.

The British journal of ophthalmology - 1 Aug 2007

Majid Mohammed A, Smith Valerie A, Newby Andrew C, Dick Andrew D

Abstract excerpt

BACKGROUND: Sorsby's fundus dystrophy (SFD) is a degenerative retinopathy characterised by accumulation of mutant TIMP-3 protein in Bruch's membrane. AIM: To compare the stability of matrix bound SFD mutant TIMP-3s with wild type TIMP-3. METHODS: COS-7 cells were transfected with plasmids containing wild type, Ser 181, Gly-167, Ser-156, and Tyr-168 TIMP-3 cDNA. The cells and their matrices were subsequently...

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Identifiers

PMID: 17383996
DOI: 10.1136/bjo.2006.113225
PMCID: PMC1954801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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