[Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer].

Abstract excerpt

Tumors arising sporadically represent 70-80% of colorectal cancer (CRC). The two best defined forms of inherited CRC-familial multiple polyposis (FMP) and Hereditary Non-Polyposis Colon Cancer (HNPCC) account respectively for<1% and 2-3% of CRC. These rare genetic syndromes (FMP, HNPCC, Peutz-Jeghers Syndrome) are caused by major predisposing gene mutations (APC gene, MMR gene, BMPR1A. SMAD4,...) and local...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenomatous Polyposis Coli
• Share to Colonic Neoplasms
• Share to Colorectal Neoplasms, Hereditary Nonpolyposis