<i>In vivo</i> and <i>ex vivo</i> comparative transcriptional profiling of invasive and non‐invasive <i>Candida albicans</i> isolates identifies genes associated with tissue invasion

Abstract excerpt

The human pathogenic fungus Candida albicans can cause a wide range of infections and invade multiple organs. To identify C. albicans genes that are expressed during invasion of the liver, we used genome-wide transcriptional profiling in vivo and ex vivo. By analysing the different phases of intraperitoneal infection from attachment to tissue penetration in a time-course experiment and by comparing the profiles...

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