[Studies on the protective effect of the mutant of Sj23 DNA vaccine against schistosomiasis].

Abstract excerpt

OBJECTIVE: To investigate the protective immunity of the vaccine against schistosomiasis, a mutant of Mr 23 000 membrane protein DNA (Sj23DNA) without the homologous sequence of ME491. METHODS: The mutant of Sj23 DNA with no homologous sequence of ME491 on the cell membrane of human melanoma was obtained by overlap PCR. The mutant was transfected into human embryonic kidney cells of the line HEK293. Indirect...

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