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Article

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein.

Oncotarget - 21 Mar 2017

Marsh Elizabeth K, Delury Craig P, Davies Nicholas J, Weston Christopher J, Miah Mohammed A L, Banks Lawrence, Parish Joanna L, Higgs Martin R, Roberts Sally

Abstract excerpt

The function of a conserved PDS95/DLG1/ZO1 (PDZ) binding motif (E6 PBM) at the C-termini of E6 oncoproteins of high-risk human papillomavirus (HPV) types contributes to the development of HPV-associated malignancies. Here, using a primary human keratinocyte-based model of the high-risk HPV18 life cycle, we identify a novel link between the E6 PBM and mitotic stability. In cultures containing a mutant genome in...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Viral

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Source

Open in PubMed Open full text

Identifiers

PMID: 28061478
DOI: 10.18632/oncotarget.14469
PMCID: PMC5386700

Genes

DLG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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