Article
Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia.
Familial cancer - 1 Jan 2007
Sokolenko Anna P, Rozanov Maxim E, Mitiushkina Natalia V, Sherina Natalia Yu, Iyevleva Aglaya G, Chekmariova Elena V, Buslov Konstantin G, Shilov Evgeny S, Togo Alexandr V, Bit-Sava Elena M, Voskresenskiy Dmitry A, Chagunava Oleg L, Devilee Peter, Cornelisse Cees, Semiglazov Vladimir F, Imyanitov Evgeny N
Abstract excerpt
Previous studies indicate that founder mutations may play a noticeable role in breast cancer (BC) predisposition in Russia. Here we performed a systematic analysis of eight recurrent mutations in 302 BC cases (St.-Petersburg, Russia), which were selected due to the presence of clinical indicators of hereditary disease (bilaterality and/or early onset (< or =40 years) and/or family history). BC-associated alleles...
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