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[Haplotype and heteroplasmy in the HV II region of mtDNA in human blood detected by PCR-DGGE].

Fa yi xue za zhi - 15 Feb 2007

Zhai Xian-dun, Huang Dai-xin, Yin Hui, Yang Qin-en

Abstract excerpt

OBJECTIVE: To establish a simple and effective technique for detecting haplotype and heteroplasmy of mtDNA, and investigate their frequencies in Chinese Han population. METHODS: The fragments from 29-290 nt of mtDNA HV II from peripheral leukocytes of 200 unrelated Wuhan Han individuals were analyzed by using PCR-DGGE technique. RESULTS: Seventeen haplotypes were found in the range of 29-290 nt, and the haplotype...

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PMID: 17330756

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