Article
No evidence of an association between tyrosine hydroxylase gene polymorphisms and suicide victims.
The Kobe journal of medical sciences - 1 Jan 2006
Hattori Haruki, Shirakawa Osamu, Nishiguchi Naoki, Nushida Hideyuki, Ueno Yasuhiro, Maeda Kiyoshi
Abstract excerpt
Functional alternations of noradrenergic and dopaminergic neurotransmission have been implicated in suicidal behavior. A tetranucleotide repeat polymorphism in the first intron of the tyrosine hydroxylase (TH) gene, encoding a rate-limiting enzyme for the synthesis of catecholamines, is reported to have the potential to control expression of the gene and to be associated with suicidal behavior in patients with...
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