Article
Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease.
Biochimica et biophysica acta - 1 May 2007
Shalova Irina N, Cechalova Katerina, Rehakova Zuzana, Dimitrova Petya, Ognibene Elisa, Caprioli Antonio, Schmalhausen Elena V, Muronetz Vladimir I, Saso Luciano
Abstract excerpt
Recently, a relationship between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the beta-amyloid precursor protein (betaAPP) in relationship with the pathogenesis of Alzheimer's disease (AD) has been suggested. Therefore, we studied the specific activity of GAPDH in the different animal models of AD: transgenic mice (Tg2576) and rats treated with beta-amyloid, or thiorphan, or lipopolysaccharides (LPS) and...
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