Article
MAP kinase pathways as regulators of fungal virulence.
Trends in microbiology - 1 Apr 2007
Román Elvira, Arana David M, Nombela César, Alonso-Monge Rebeca, Pla Jesús
Abstract excerpt
MAP kinases are dual phosphorylated protein kinases, present in eukaryotes, which mediate differentiation programs and immune responses in mammalian cells. In pathogenic fungi, MAP kinases are key elements that control adaptation to environmental stress. Recent studies have shown that these pathways have an essential role in the control of essential virulence factors such as capsule biogenesis in Cryptococcus...
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