Article
Immunogenicity of virus-like particles containing modified human immunodeficiency virus envelope proteins.
Vaccine - 10 May 2007
Quan Fu-Shi, Sailaja Gangadhara, Skountzou Ioanna, Huang Chunzi, Vzorov Andrei, Compans Richard W, Kang Sang-Moo
Abstract excerpt
Extensive glycosylation and variable loops of the HIV envelope protein (Env) are reported to shield some neutralizing epitopes. Here, we investigated the immunogenicity of mutated HIV Envs presented in virus-like particles (VLPs). We immunized mice with simian human immunodeficiency virus (SHIV) VLPs containing mutant HIV Env with reduced glycosylation (3G), variable loop-deleted mutations (dV1V2), or...
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