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Article

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Jun 2007

Bonifacio Alois, Groenhof André R, Keizers Peter H J, de Graaf Chris, Commandeur Jan N M, Vermeulen Nico P E, Ehlers Andreas W, Lammertsma Koop, Gooijer Cees, van der Zwan Gert

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is one of the most important cytochromes P450 in humans. Resonance Raman data from the T309V mutant of CYP2D6 show that the substitution of the conserved I-helix threonine situated in the enzyme's active site perturbs the heme spin equilibrium in favor of the six-coor...

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Identifiers

PMID: 17318599
DOI: 10.1007/s00775-007-0210-5
PMCID: PMC1915625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17318599-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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