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HIV entry inhibition by the envelope 2 glycoprotein of GB virus C

20 Feb 2007

Abstract excerpt

Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the...

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PMID: 17314528
DOI: 10.1097/qad.0b013e32803277c7

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