Article
Activity of the beta-myosin heavy chain antisense promoter responds to diabetes and hypothyroidism.
American journal of physiology. Heart and circulatory physiology - 1 Jun 2007
Giger Julia, Qin Anqi X, Bodell Paul W, Baldwin Kenneth M, Haddad Fadia
Abstract excerpt
Two genes encoding cardiac myosin heavy chain (MHC) isoforms, beta and alpha, are arranged in tandem 4.5 kb apart. We examined pre-mRNA and mature mRNA levels of beta and alpha genes in control, diabetic (streptozotocin), hypothyroid (propylthiouracil), and hyperthyroid rat hearts and analyzed the naturally occurring antisense (AS) beta RNA species that starts in the middle of the 4.5-kb intergenic region and...
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