Article
Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes.
Journal of hypertension - 1 Mar 2007
van Rijn Marie Josee E, Schut Anna F C, Aulchenko Yurii S, Deinum Jaap, Sayed-Tabatabaei Fakhredin A, Yazdanpanah Mojgan, Isaacs Aaron, Axenovich Tatiana I, Zorkoltseva Irina V, Zillikens M Carola, Pols Huib A P, Witteman Jacqueline C M, Oostra Ben A, van Duijn Cornelia M
Abstract excerpt
OBJECTIVE: To study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes. METHODS: All participants are members of an extended pedigree from a Dutch genetically isolated population. Heritability and genetic correlations of systolic blood pressure, diastolic blood pressure, mean arterial pressure and pulse pressure were assessed using a...
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