Article
A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidality.
International journal of molecular medicine - 1 Mar 2007
Minoretti Piercarlo, Arra Mariarosa, Emanuele Enzo, Olivieri Valentina, Aldeghi Alessia, Politi Pierluigi, Martinelli Valentina, Pesenti Sara, Falcone Colomba
Abstract excerpt
The forkhead/winged helix box (FOX) gene family comprises at least 43 different genes encoding transcriptional factors with a highly conserved DNA-binding domain. To date, mutations in members of the FOX gene family have been causally linked to a variety of different human diseases. We describe a three-generation Albanian pedigree in which a complex phenotype consisting of dilated cardiomyopathy,...
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