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Article

6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism.

Journal of agricultural and food chemistry - 7 Feb 2007

Chen Chung-Yi, Liu Tsan-Zon, Liu Yi-Wen, Tseng Wei-Chang, Liu Ray H, Lu Fung-Jou, Lin Yu-Shan, Kuo Shih-Hsien, Chen Ching-Hsein

Abstract excerpt

Mahlavu cells, poorly differentiated and p53 mutants of a human hepatoma subline, are known to be highly refractory to a number of chemotherapeutic agents and radiotherapy due to their high expressions of multidrug resistance gene-1 (MDR-1) and Bcl-2 proteins. Thus, it is desirable to search for an alternative strategy for effective eradication of this type of cancer cells. We present evidence here for the first...

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Identifiers

PMID: 17263498
DOI: 10.1021/jf0624594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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