Variation in pleiotropy and the mutational underpinnings of the G-matrix.

Abstract excerpt

The pattern and extent of pleiotropic gene action can contribute substantially to the internal structure and shape of the additive genetic variance-covariance matrix (G)--a key determinant of evolutionary trajectories. We use data from our study (Estes et al. 2004) on the univariate effects of mutation in a mismatch-repair-defective strain, msh-2, of Caenorhabditis elegans to address the impact of increasing...

Topics

• Animals
• Caenorhabditis elegans
• Genetic Variation
• Inheritance Patterns
• Mutation
• Selection, Genetic