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Article

Probabilistic analysis of recessive mutagenesis screen strategies.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2007

Silver Jeremy D, Hilton Douglas J, Bahlo Melanie, Kile Benjamin T

Abstract excerpt

Random mutagenesis screens for recessive phenotypes require three generations of breeding, using either a backcross (BC) or intercross (IC) strategy. Hence, they are more costly and technically demanding than those for dominant phenotypes. Maximizing the return from these screens requires maximizing the number of mutations that are bred to homozyosity in the G(3) generation. Using a probabilistic approach, we...

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Identifiers

PMID: 17245609
DOI: 10.1007/s00335-006-0057-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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