Article
The carboxy-terminal domain of glycoprotein N of human cytomegalovirus is required for virion morphogenesis.
Journal of virology - 1 May 2007
Mach Michael, Osinski Karolina, Kropff Barbara, Schloetzer-Schrehardt Ursula, Krzyzaniak Magdalena, Britt William
Abstract excerpt
Glycoproteins M and N (gM and gN, respectively) are among the few proteins that are conserved across the herpesvirus family. The function of the complex is largely unknown. Whereas deletion from most alphaherpesviruses has marginal effects on the replication of the respective viruses, both proteins are essential for replication of human cytomegalovirus (HCMV). We have constructed a series of mutants in gN to...
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