Article
Metastatic cancer cells from c-erbB-2 negative primary breast cancer maintain the original c-erbB-2/HIF1alpha phenotype.
Cancer biology & therapy - 1 Feb 2007
Giatromanolaki Alexandra, Koukourakis Michael I, Simopoulos Costantinos, Sivridis Efthimios
Abstract excerpt
The expression of c-erbB-2 and HIF1alpha proteins is linked with an aggressive tumor phenotype and poor survival in breast cancer. In the present study we investigated whether this ominous effect is a result of c-erbB-2/HIF1alpha expressing clone appearance within the primary tumor, by examining...
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