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Article

A gene expression screen.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991

Wang Z, Brown D D

Abstract excerpt

A gene expression screen identifies mRNAs that differ in abundance between two mRNA mixtures by a subtractive hybridization method. The two mRNA populations are converted to double-stranded cDNAs, fragmented, and ligated to linkers for polymerase chain reaction (PCR) amplification. The multiple cDNA fragments isolated from any given gene can be treated as alleles in a genetic screen. Probability analysis of the...

Topics

Alleles
Animals
Base Sequence
Chromosome Mapping
DNA
Gene Expression
Metamorphosis, Biological
Molecular Sequence Data
Nucleic Acid Hybridization
Oligodeoxyribonucleotides
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA

RNA, Messenger

Restriction Mapping

Tail

Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 1722336
DOI: 10.1073/pnas.88.24.11505
PMCID: PMC53164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1722336-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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