Article
No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2007
Schimmelmann B G, Friedel S, Dempfle A, Warnke A, Lesch K P, Walitza S, Renner T J, Romanos M, Herpertz-Dahlmann B, Linder M, Schäfer H, Seitz C, Palmason H, Freitag C, Meyer J, Konrad K, Hinney A, Hebebrand J
Abstract excerpt
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable common neurodevelopmental disorder with onset in childhood. A coding SNP (rs6265, Val66Met) of the brain-derived neurotrophic factor gene (BDNF) has recently been associated with ADHD. More specifically, paternal over-transmission of the common Val66 allele to affected children had been observed. We aimed to confirm these findings in a large,...
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