Article
A cluster of highly polymorphic dinucleotide repeats in intron 17b of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
American journal of human genetics - 1 Dec 1991
Zielenski J, Markiewicz D, Rininsland F, Rommens J, Tsui L C
Abstract excerpt
A cluster of highly polymorphic dinucleotide repeats has been detected in intron 17b of the CFTR gene, 200 bp downstream from the preceding exon. At least 24 alleles, with sizes ranging from 7 to 56 units of a TA repeat, have been identified in a panel of 92 unrelated carriers of cystic fibrosis...
Topics
- Adenine Nucleotides
- Base Sequence
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Cytosine Nucleotides
- Genes, Regulator
- Genetic Linkage
- Humans
- Introns
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Thymine Nucleotides