Article
Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients.
Molecular psychiatry - 1 May 2007
Ruaño G, Goethe J W, Caley C, Woolley S, Holford T R, Kocherla M, Windemuth A, de Leon J
Abstract excerpt
Atypical antipsychotics induce pre-diabetic symptoms in some but not all patients, characterized most notably by elevated weight. The side effect profiles of the various drugs in the class differ, however, raising the possibility of drug-specific mechanisms for similar side effects. We used physiogenomic analysis, an approach previously employed to study the genetics of drug and diet response, to discover and...
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