Article
Recombinant gp135 envelope glycoproteins of caprine arthritis-encephalitis lentivirus variants inhibit homologous and heterologous variant-specific neutralizing antibodies.
Virology - 1 Nov 1991
Lichtensteiger C A, Knowles D P, McGuire T C, Cheevers W P
Abstract excerpt
The envelope (env) genes of two antigenic variants of caprine arthritis-encephalitis virus (CAEV), defined by serum neutralization, were expressed in vaccinia virus. Recombinant gp135 envelope glycoprotein competitively inhibited neutralizing activity of serum from CAEV-infected goats, indicating...
Topics
- Animals
- Antibodies, Viral
- Arthritis-Encephalitis Virus, Caprine
- Base Sequence
- Cell Line
- Cells, Cultured
- Codon
- Epitopes
- Gene Products, env
- Genes, env
- Genetic Variation
- Goats
- Humans
- Molecular Sequence Data
- Neutralization Tests
- Recombinant Proteins
- Restriction Mapping
- Synovial Membrane