Article
Loss of introns along the evolutionary diversification pathway of snake venom disintegrins evidenced by sequence analysis of genomic DNA from Macrovipera lebetina transmediterranea and Echis ocellatus.
Journal of molecular evolution - 1 Feb 2007
Bazaa Amine, Juárez Paula, Marrakchi Néziha, Bel Lasfer Zakaria, El Ayeb Mohamed, Harrison Robert A, Calvete Juan J, Sanz Libia
Abstract excerpt
Analysis of cDNAs from Macrovipera lebetina transmediterranea (Mlt) and Echis ocellatus (Eo) venom gland libraries encoding disintegrins argued strongly for a common ancestry of the messengers of short disintegrins and those for precursors of dimeric disintegrin chains. We now report the sequence analysis of disintegrin-coding genes from these two vipers. Genomic DNAs for dimeric disintegrin subunits Ml_G1 and...
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