Multiple cytokine interactions regulate Ly-6E antigen expression: cooperative Ly-6E induction by IFNs, TNF, and IL-1 in a T cell lymphoma and in its induction-deficient variants.

doi:10.1016/0008-8749(91)90135-x

Back to search

Article

Multiple cytokine interactions regulate Ly-6E antigen expression: cooperative Ly-6E induction by IFNs, TNF, and IL-1 in a T cell lymphoma and in its induction-deficient variants.

Cellular immunology - 1 Nov 1991

Altmeyer A, Staruch M J, Cofano F, Landolfo S, Dumont F J

Abstract excerpt

The cell surface Ly-6E antigen, known to play a role in T cell activation, is up-regulated by IFNs. In the present study, we investigated the possible interactions between IFNs and other cytokines in this regulation. As a model system, we used the YAC T cell lymphoma, in which Ly-6E is normally a...

Topics

Antigens, Ly
Cyclic AMP
Drug Synergism
Humans
Interferons
Interleukin-1
Lymphoma, T-Cell
Mutation
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.