Isolation of Germ Cells from Leukemia and Lymphoma Cells in a Human <i>In vitro</i> Model: Potential Clinical Application for Restoring Human Fertility after Anticancer Therapy

Abstract excerpt

More than 70% of patients survive childhood cancer, but chemotherapy and radiation therapy may cause irreversible impairment of spermatogenesis. To treat infertility secondary to anticancer treatment for childhood cancer, we have developed a procedure to isolate germ cells from leukemic mice by fluorescence-activated cell sorting with two surface markers, and transplantation of isolated germ cells successfully...

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