Article
Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis.
Hepatology (Baltimore, Md.) - 1 Dec 2006
Primignani Massimo, Barosi Giovanni, Bergamaschi Gaetano, Gianelli Umberto, Fabris Federica, Reati Raffaella, Dell'Era Alessandra, Bucciarelli Paolo, Mannucci Pier Mannuccio
Abstract excerpt
The diagnosis of an underlying chronic myeloproliferative disorder (CMPD) is often problematic in patients with primary extrahepatic portal vein obstruction (EHPVO) or Budd-Chiari syndrome (BCS); indeed, conventional clinical and hematological parameters usually yield insufficient information. To assess the diagnostic contribution of the gain-of-function mutation V617F of the JAK2 gene, 93 patients with EHPVO or...
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