Article
[Where is the role of the genetic investigations in amyotrophic lateral sclerosis?].
Revue neurologique - 1 Jun 2006
Vandenberghe N
Abstract excerpt
About 10 p. cent of amyotrophic lateral sclerosis (ALS) cases are familial. Most of the familial ALS (FALS) cases are clinically homogeneous. Among these families, autosomal dominant, X-linked or autosomal recessive transmission can be observed. Most of the causal mutations have been observed in the SOD1 gene. To date, more than one hundred different mutations have been described, but it remains unclear whether...
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