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Article

Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration.

Annals of the rheumatic diseases - 1 Apr 2007

Steer Sophia E, Williams Frances M K, Kato Bernet, Gardner Jeffry P, Norman Paul J, Hall Margaret A, Kimura Masayuki, Vaughan Robert, Aviv Abraham, Spector Tim D

Abstract excerpt

BACKGROUND: Rheumatoid arthritis (RA) is associated with reduced lifespan and shortened telomere length in lymphocytes, but the mechanism underlying this is unclear. Telomere loss in white blood cells (WBC) is accelerated by oxidative stress and inflammation in vitro. It was postulated that the accelerated WBC telomere shortening in RA occurs as a result of exposure to chronic inflammation. OBJECTIVES: To measure...

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Identifiers

PMID: 17114192
DOI: 10.1136/ard.2006.059188
PMCID: PMC1856061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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