Article
Dr(a-) polymorphism of decay accelerating factor. Biochemical, functional, and molecular characterization and production of allele-specific transfectants.
The Journal of clinical investigation - 1 Jun 1991
Lublin D M, Thompson E S, Green A M, Levene C, Telen M J
Abstract excerpt
The Dra antigen belongs to the Cromer-related blood group system, a series of antigens on decay accelerating factor (DAF), a glycosyl-phosphatidylinositol-anchored membrane protein that protects host cells from complement-mediated damage. We studied the rare inherited Dr(a-) phenotype to ascertain the associated biochemical and functional changes in DAF and to characterize the basis for this polymorphism....
Topics
- Alleles
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Blood Group Antigens
- Blotting, Western
- CD55 Antigens
- Glycolipids
- Glycosylphosphatidylinositols
- Hemoglobinuria, Paroxysmal