Article
Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype.
Cellular microbiology - 1 Mar 2007
Kato Takahiro, Kawai Shinji, Nakano Kazuhiko, Inaba Hiroaki, Kuboniwa Masae, Nakagawa Ichiro, Tsuda Kayoko, Omori Hiroko, Ooshima Takashi, Yoshimori Tamotsu, Amano Atsuo
Abstract excerpt
Porphyromonas gingivalis is a periodontal pathogen whose fimbriae are classified into six genotypes based on the diversity of the fimA genes encoding each fimbria subunit. It was suggested that P. gingivalis strains with type II fimbriae were more virulent than type I strains. For the present study, we generated the mutants in which fimA was substituted with different genotypes to study virulence of type II...
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