Familial breast cancer, underlying genes, and clinical implications: a review.

doi:10.1615/critrevoncog.v12.i1-2.50

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Article

Familial breast cancer, underlying genes, and clinical implications: a review.

Critical reviews in oncogenesis - 1 Jul 2006

Margolin Sara, Lindblom Annika

Abstract excerpt

Family history has been a recognized risk factor for breast cancer for many years. We will, in this review, describe the research field in breast cancer susceptibility from the early epidemiological, loss of heterozygosity (LOH), and linkage studies in the 1990s leading to the discovery of BRCA1 and 2, and the subsequent search for other high- and low-risk genes at present. We will also describe the clinical...

Topics

Breast Neoplasms
DNA Repair
Female
Genes, BRCA1
Genes, BRCA2
Genes, Neoplasm
Genes, p53
Genetic Counseling
Genetic Predisposition to Disease
Humans
Mutation
Pedigree

Source

Open in PubMed

Identifiers

PMID: 17078207
DOI: 10.1615/critrevoncog.v12.i1-2.50

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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