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Article

Expression and functional study of wild-type and mutant human cytochrome P450c21 in Saccharomyces cerevisiae.

DNA and cell biology - 1 Apr 1991

Wu D A, Hu M C, Chung B C

Abstract excerpt

The most common cause of congenital adrenal hyperplasia is deficiency of cytochrome P450c21 (21-hydroxylase), which catalyzes the synthesis of adrenal steroids. We have cloned the human P450c21 cDNA into yeast expression vectors under the control of either the glyceraldehyde-3-phosphate-dehydrogenase (GAPDH) promoter or the aldehyde-dehydrogenase (ADH) promoter. P450c21 RNA, protein, and enzyme activity can be...

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Source

Identifiers

PMID: 1707279
DOI: 10.1089/dna.1991.10.201

Genes

GAPDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression and functional study of wild-type and mutant human cytochrome P450c21 in Saccharomyces cerevisiae.PMID 1707279Read ↗

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