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Association of chemokine receptor 5 (CCR5) delta32 mutation with Behçet's disease is dependent on gender in Iranian patients.

Clinical and experimental rheumatology - 1 Jan 2000

Mojtahedi Z, Ahmadi S B, Razmkhah M, Azad T K, Rajaee A, Ghaderi A

Abstract excerpt

OBJECTIVE: Behçet's disease (BD) is a recurrent multi-system inflammatory disorder caused by the combinations of multiple genetic and environmental factors. CCR5 is a Th1-dominant chemokine receptor whose levels are increased in patients with active BD. It is believed that a 32 bp deletion in the CCR5 gene reduces the expression of this receptor on the cell surface. The aim of the present study was to investigate...

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PMID: 17067435

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CCR5

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