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Article

Effects of globin mRNA reduction methods on gene expression profiles from whole blood.

The Journal of molecular diagnostics : JMD - 1 Nov 2006

Liu Jinny, Walter Elizabeth, Stenger David, Thach Dzung

Abstract excerpt

Excessive globin mRNA in whole blood RNA decreases transcript detection sensitivity and increases signal variation on microarrays. Hence, methods based on peptide nucleic acid inhibitory oligos and biotinylated DNA capture oligos have been developed to reduce globin mRNA. However, there is limited information about the effects of these two methods on gene expression profiles. Thus, we systematically compared the...

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Identifiers

PMID: 17065423
DOI: 10.2353/jmoldx.2006.060021
PMCID: PMC1876175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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