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Mitochondrial damage modulates alternative splicing in neuronal cells: implications for neurodegeneration

23 Aug 2006

Abstract excerpt

Mitochondrial damage is linked to many neurodegenerative conditions, such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. These diseases are associated with changes in the splicing pattern of individual mRNAs. Here, we tested the hypothesis that mitochondrial damage modulates alternative splicing, not only of a few mRNAs, but in a general manner. We incubated cultured human...

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PMID: 17064354
DOI: 10.1111/j.1471-4159.2006.04204.x

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