Article
Interleukin-18 promoter polymorphisms in patients with Behçet's disease.
Human immunology - 1 Oct 2006
Lee Yun Jong, Kang Seong Wook, Park Jeong Jin, Bae Young Deok, Lee Eun Young, Lee Eun Bong, Song Yeong Wook
Abstract excerpt
Behçet's disease (BD) is an idiopathic systemic inflammatory disease and is considered to be a T helper 1 (Th1) type cytokine driven disorder. Moreover, levels of interleukin-18 (IL-18), a pivotal mediator of Th1 cytokine response, have been reported to be upregulated in BD. Therefore, we investigated the distribution of IL-18 promoter -607 C/A and -137 G/C polymorphisms in 103 BD patients (mean age 41.0 years;...
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