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<i>Helicobacter pylori</i>HopH (OipA) and Bacterial Pathogenicity: Genetic and Functional Genomic Analysis of<i>hopH</i>Gene Polymorphisms

17 Oct 2006

Abstract excerpt

BACKGROUND: Expression of the Helicobacter pylori outer membrane protein HopH is regulated by phase variation within a CT dinucleotide repeat motif of the hopH gene. METHODS: To investigate the importance of HopH for bacterial pathogenicity, we performed a detailed functional genomic and population-based genetic characterization of this contingency locus. RESULTS: Sequencing of hopH in H. pylori strains from 58...

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PMID: 17054063
DOI: 10.1086/508426

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