Article
Familial amyotrophic lateral sclerosis: a SOD1-unrelated Japanese family of bulbar type with Bunina bodies and ubiquitin-positive skein-like inclusions in lower motor neurons.
Acta neuropathologica - 1 Feb 2007
Tagawa Asako, Tan Chun-Feng, Kikugawa Koki, Fukase Masayuki, Nakano Ryoichi, Onodera Osamu, Nishizawa Masatoyo, Takahashi Hitoshi
Abstract excerpt
We describe a new family with adult onset amyotrophic lateral sclerosis (FALS), in which the disease was characterized clinically by relatively rapid progression of bulbar symptoms. Gene analysis of Cu/Zn superoxide dismutase (SOD1) performed in one patient showed no mutations. Autopsy of another...
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