Article
Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS.
Journal of neuropathology and experimental neurology - 1 Oct 1998
Ince P G, Tomkins J, Slade J Y, Thatcher N M, Shaw P J
Abstract excerpt
Molecular pathology has identified 2 distinct forms of neuronal inclusion body in Amyotrophic Lateral Sclerosis (ALS). ALS-type inclusions are skeins or small dense filamentous aggregates which can only be demonstrated by ubiquitin immunocytochemistry (ICC). In contrast hyaline conglomerates (HC)...
Topics
- Aged
- Amyotrophic Lateral Sclerosis
- Brain
- Female
- Humans
- Inclusion Bodies
- Male
- Microscopy, Confocal
- Middle Aged
- Motor Neurons
- Mutation
- Nerve Degeneration
- Spinal Cord
- Superoxide Dismutase